Diabetes presentation -- Introduction to different types of diabetes and their inheritance patterns. Includes case scenarios designed to promote critical thinking and problem solving skills. Provides practice in recognizing inheritance patterns and why different individuals/families may require different counseling about diabetes risks and dietary interventions.
Distinguishing different types of diabetes in children and young adults -- Although type 1 diabetes is the most common type of diabetes in children, it is becoming more common to see children, adolescents, and young adults with type 2 diabetes.
Useful websites:
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Genetics and Diabetes -- Information from the Joslin Diabetes Center answering questions about diabetes risks |
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American Diabetes Association -- Basic information, information on clinical trials, and information for health care professionals |
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Diabetes Facts -- Basic information about diabetes from the Canadian Diabetes Association |
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Pregnancy and Diabetes -- NIH information and links to more information |
| Molecular Genetics of Diabetes Mellitus -- An article summarizing research on genetics and diabetes by Graeme Bell, one of the scientists continuing to do research in this area |
| Heterogeneity of Diabetes: Several exemplary syndromes -- A resource describing genetic syndromes associated with diabetes, geared to physicians and other medical professional. |
| Diabetes Statistics -- Produced using U.S. survey data by the National Diabetes Information Clearinghouse |
| Children with Diabetes -- Online community for children, teens and adults with diabetes. It includes a chat room and question board with answers from health care professionals. |
Journal References:
| nMcFarlane, SI et al. Insulin Resistance and Cardiovascular Disease. Journal of Endocrinology and Metabolism 86 (2) 2001 |
| Knowler WC et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002 Feb 7;346(6):393-403 |
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nAmerican Diabetes
Association. Type 2 Diabetes in
Children. Pediatrics 105
(3) 2000
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nHaiyan, L et al.
Possible Human Leukocyte antigen-Mediated Genetic Interaction
Between Type 1 and Type 2 Diabetes. Journal of Endocrinology and
Metabolism 86 (2) 2001
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| Hamdy, O et al. Diet and Exercise in Type 2 Diabetes Mellitus. Endocrinology and Metabolism Clinics 30 (4) 2001 |
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| Robles, DT et al. The genetics of autoimmune polyendocrine syndrome type II. Endocrinology and Metabolism Clinics 31 (2) 2002 |
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| Winter, WE et al. Monogenic Diabetes Mellitus in Youth. Endocrinology and Metabolism Clinics 28 (4) 1999 |
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nZalloua,
PA et al. Type 2 Diabetes Family
History delays the Onset of Type-1 Diabetes. Journal of Endocrinology
and Metabolism 87 (7) 2002.
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Becher, DJ et al. Prevention and Treatment of Diabetes in Children. Journal of Endocrinology and Metabolism 85 (2) 2000 |
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Wei M et al. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 1999 Jan 19;130(2):89-96 |
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Hu FB et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001 Sep 13;345(11):790-7 |
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Weyer C et al. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 2000 Dec;43(12):1498-506 |
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Adamson AJ. Non-diabetic relatives of Type 2 diabetic families: dietary intake contributes to the increased risk of diabetes. Diabet Med - 01-Dec-2001; 18(12): 984-90 |
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Wasmuth HE. Cow's milk and immune-mediated diabetes. Proc Nutr Soc - 01-Nov-2000; 59(4): 573-9 |
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Astrup A. Healthy lifestyles in Europe: prevention of obesity and type II diabetes by diet and physical activity. Public Health Nutr - 01-Apr-2001; 4(2B): 499-515 |
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Berdanier CD. Diabetes and nutrition: the mitochondrial part. J Nutr - 01-Feb-2001; 131(2): 344S-53S |
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Maier S. Diabetes: a candidate disease for efficient DNA methylation profiling. J Nutr - 01-Aug-2002; 132(8 Suppl): 2440S-2443S |
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Owen K, Hattersley AT 2001 Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization. Best Pract Res Clin Endocrinol Metab 15:309–323 |
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Fajans SS, Bell GI, Polonsky KS 2001 Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 345: 971–980 |
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Hani EH, Stoffers DA, Chevre JC, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P 1999 Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late onset type 2 diabetes mellitus. J Clin Invest 104:R41–R48 |
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Wareham, NJ et al.
Establishing the role of gene-environment interactions in the
etiology of type 2 diabetes. Endocrinology and Metabolism Clinics 31
(3) 2002
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Tayor, SI and Arioglu E. Genetically Defined Forms of Diabetes in Children. Journal of Endocrinology and Metabolism 84 (12) 1999 |
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nFlorence,
JA and Yeager, BF. Treatment of
Type 2 Diabetes Mellitus.
American family Physician 59 (10) 1999
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